Deputy Minister of Higher Education, Science, and Innovation, Mr Buti Manamela, spoke at the Basic Education Lekgotla on the impact of Artificial Intelligence (AI) on education, employability, and society. AI is changing the way we learn, communicate, and work, but it is important to ensure that it remains accessible, fair, and ethical for everyone. The use of AI in education is creating inclusive and efficient learning environments, but challenges such as data confidentiality and algorithmic prejudice need to be addressed. The automation of labor markets through AI is creating opportunities for innovation and entrepreneurship, but promoting lifelong learning and upskilling is crucial to ensure the future workforce is prepared. South Africa’s efficient science, technology, and innovation (STI) reaction to the COVID19 pandemic provides valuable lessons for navigating the AI transformation and its impact on education, employability, and society.