The National Status of Biological Invasives and their Management report emphasizes the urgent need to prevent, detect, and control invasive species in South Africa. This threat not only harms biodiversity but also impacts various sectors of the economy, agriculture, water resources, and public health. South Africa has implemented an effective regulatory system to manage biological invasions and is a vanguard in invasion science. However, addressing biological invasions requires a united response from all sectors, and the report serves as a wakeup call to act decisively.