PEPFAR, the US President’s Emergency Plan for AIDS Relief, is a crucial program that started in 2003 to fight the AIDS epidemic, especially in Africa. It has provided lifesaving treatments and education, saving many lives over the years. However, recent funding disruptions have put this success at risk, causing many health centers in South Africa to close or reduce services. These challenges threaten not only individual health but also the progress made against HIV, showing how important it is to keep global health efforts strong and steady.