The City of Cape Town is taking significant steps to combat HIV and TB by implementing new policies and guidelines, such as Post Exposure Prophylaxis (PEP) and PreExposure Prophylaxis (PrEP) to motivate people to evaluate their HIV status and offer alternatives for those at risk. The City’s approach focuses on social, biomedical, and behavioural aspects and serves as a model for other cities. The City has seen a substantial increase in HIV selftests, and prevention strategies aim to reduce the untested population. The City’s dedication to combating HIV and TB goes beyond biomedical and behavioural approaches and addresses the social determinants of health.